Enterprise Risk Management (ERM): Assessment of Environmental and Social Risks from ERM Perspective

Factors that affect the adoption of Enterprise Risk Management (ERM)

Risk Management (RM) is rapidly evolving; its practitioners are increasingly shifting focus from pure operational or financial risks to a broader Enterprise Risk Management (ERM). ERM involves a set of processes and methods used to manage risks that are not just associated with accidental losses but also associated with financial, strategic, technological and other business areas. This article ...

ERM proteins

compensate for one another, although there is no evidence of true biochemical redundancy. The genomes of lower organisms, such as Caenorhabditis elegans, Drosophila melanogaster and Danio rerio, harbor single ERM orthologues; in fact, ERMs appeared evolutionarily during the transition to multicellularity and an ERM-like protein is encoded by the genome of the choanoflagellate Monosiga brevicoli...

ERM immersion vaccination and adjuvants

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.

ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells. ERM activity is regulated in part by phosphorylation at a C-terminal threonine, but the identity of ERM kinases is unknown in lymphocytes and incompletely defined in other mammalian cells. Our studies show that lymphocyte-oriented kinase (LOK) is an ERM kinase in vitro and in vivo. Mass s...

Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.

The Erm family of methyltransferases confers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methylation of 23S ribosomal RNA. Upon the methylation of RNA, the MLS antibiotics lose their ability to bind to the ribosome and exhibit their antibiotic activity. Using an NMR-based screen, we identified a series of triazine-containing compounds that bind wea...